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This is followed by a modest decline during the ovulatory phase.E2 levels then gradually increase again until the midpoint of the luteal phase and thereafter decline to trough, early follicular levels.Low baseline levels and a lack of rise, as well as persistent high levels without midcycle rise are indicative of anovulatory cycles.For determining the timing of initiation of ovarian stimulation in in vitro fertilization studies, low levels (around 30 pg/m L) before stimulation are critical, as higher values often are associated with poor stimulation cycles.ADULTS Males: 10-60 pg/m L Females Premenopausal: 17-200 pg/m L Postmenopausal: 7-40 pg/m L Conversion factor E1: pg/m L x 3.704=pmol/L (molecular weight=270) ESTRADIOL (E2) CHILDREN* 1-14 days: Estradiol levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.Males #Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 ( /- 2) years.This can have functional causes, such as starvation, overexercise, severe physical or emotional stress, and heavy drug and/or alcohol use.

In addition, it is widely used for monitoring ovulation induction, as well as during preparation for in vitro fertilization.

For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Tanner stage V (adult) should be reached by age 18.

Females #Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 ( /- 2) years.

Further work-up is required and usually includes measurement of total and bioavailable testosterone, androstenedione, dehydroepiandrosterone (sulfate), sex hormone-binding globulin, and possibly imaging.

E2 analysis may be helpful in establishing time of ovulation and optimal time for conception.

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