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But since protein blocks serotonin synthesis, eating a meal containing protein will actually cause both tryptophan and serotonin levels drop.

However, tryptophan supplements can increase brain serotonin even though eating foods containing tryptophan does not (5).

Before you take any serotonin supplement, it’s important to understand a little bit about them and especially how they work together.

Sometimes there are vital synergistic relationships between these various serotonin boosting substances.

SAM-e (s-adenosyl methionine): SAM-e naturally occurs in every cell of the body and brain and fuels over 100 metabolic reactions. In Europe, SAM-e is used as a prescription medication for depression, liver disease, and osteoarthritis (11).

SAM-e supplements are synthetically derived and sold in the U. Several studies show that SAM-e works as well for depression as some anti-depression medications by increasing serotonin, dopamine, and other “feel good” brain chemicals (12, 13).

Elsewhere in Europe, it’s available as a prescription drug (8).

Unfortunately, this supplement’s usefulness for depression may be more hype than substance.

For decades, manufacturers shied away from selling this supplement, but it’s now readily available and widely known to be safe.Do so only if you are working with a knowledgeable health care professional. Tryptophan: Tryptophan might seem like a logical serotonin supplement to try first since tryptophan is a precursor of serotonin.Together, they can cause too large an increase in serotonin, which can result in a potentially serious condition known as serotonin syndrome. Tryptophan is an amino acid commonly found in protein-rich foods like animal products.If this is your situation, here are some serotonin supplements proven to help increase serotonin levels naturally.There are many kinds of nutritional supplements that increase serotonin levels — amino acids, vitamins, minerals, herbs, and more.

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