Elucidating the role of 8q24 in colorectal cancer
TGF-β pathway is also involved in the prognosis of the CRC ( 8 ), and overexpression of TGF-β signaling genes has been known to play a vital role in the progression of CRC ( 9 ).However, whether these GWAS-identified cancer susceptibility SNPs affect CRC clinical outcomes remains unclear.
The study end points were overall survival and recurrence.
Five SNPs: rs961253 (20p12.3), rs355527 (20p12.3), rs4464148 (18q21.1), rs6983267 (8q24.21) and rs10505477 (8q24.21) in three regions were significantly associated with survival for patients with stage III disease.
Cumulative effects of multiple unfavorable genotypes were observed for recurrence and survival in patients with stage III CRC.
Demographic and epidemiologic data were collected using a structured self-administered questionnaire.
All study patients donated 10–20 ml blood sample for genomic DNA isolation and molecular analyses.